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Title:Epigenetics Research
Description:Epigenetics Research Portal - articles, jobs, lab registry, news, forum - updated daily
Keywords:epigenetics, dna methylation
Body:
Epigenetics Research
Epigenetics Research
Free epigenetics newsletter
Search our entire network:
Home
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What is epigenetics?
Definition
Nucleosome etched in crystal
Epigenetics refers to DNA and chromatin modifications that persist from one cell division to the next despite a lack of change
in the underlying DNA sequence. Some epigenetic changes show transgenerational inheritance meaning that these changes can
be passed from one generation to the next. Epigenetics plays an important role in cellular differentiation, allowing dinstict
cell types to have specific characteristics despite sharing the same DNA sequence. Some examples of epigenetic processes include
imprinting, bookmarking, gene silencing, paramutation, X chromosome inactivation, reprogramming,
position effect, histone modifications and heterochromatin, some carcinogenesis, maternal effects, and transvection.
The epigenome refers to the overall epigenetic state of a cell while the epigenetic code refers to epigenetic features such as
DNA methylation and histone modifications that create different phenotypes in different cells.
Epigenetic mechanisms
The mechanisms of epigenetic inheritance systems are still being unraveled, but our current understanding has uncovered at least
4 routes by which epigenetic changes persist over time. These routes include RNA transcripts, cellular structures,
DNA methylation/chromatin remodeling, and even prions:
The expression of certain genes can enhance the production of other similar genes,
and even the gene itself. The enhanced expression of certain genes can be inherited by subsequent descendents.
This can be through transcription factors and signal transduction pathways; in systems containing gap junctions, the actual mRNA may be spread
to other cells or nuclei via diffusion. During oogenesis, a large amount of RNA and protein is contributed to the zygote by the mother, leading to
maternal effect phenotypes.
Structural inheritance is common in ciliates such as paramecium where the pattern of ciliary rows is inherited from one generation to the next.
The existing structure of the ciliary rows acts as a template for new structures.
Histones
DNA associates with histones to form chromatin. Gene expression can be regulated through chromatin remodeling which arises from either
post-translational modification of histones or DNA methylation (conversion of cytosine to 5-methylcytosine). Histone tails are the most
heavily modified region, and modifications include acetylation, methylation, and ubiquitylation. Histone acetylation by
histone acetyltranferase enzymes (HATs) are associated with transcriptional competence. This series of histone modifications is known
as the histone code. Now, nucelosomes (DNA complexed with histones) are not totally removed during DNA replication and the modified
embed
histones can act as a template, allowing for inheritance of histone modifications in the daughter cell. DNA methylation often occurs in repetitive
DNA sequences and acts to suppress "junk" DNA. The most common type of methylation event is the methylation at the 5' position of cytosine.
In adult tissue, methylation usually occurs at CpG dinucleotide sites while in embryonic stem cells, this dinucleotide propensity is not
important. The resulting 5-methylcytosine residues are more susceptible to mutation and therefore CpG regions are relatively rare except in
CpG islands which are composed of long (300-3000 bp) stretches of GC nucleotides and are in or near 40% of promoters of mammalian genes. These
CpG islands are less likely to be methylated. DNA methylation patterns are determined by an interplay between the environment and 3 independent
DNA methyltransferases (DNMT1, DNMT3A, DNMT3B). Histone deacetylation is depicted in the above video.
Importance of epigenetics
Epigenetics is important in development partly because the genome is largely static. Epigenetic modifications are required to provide some dynamic
variability to cellular function and phenotype, allowing for cellular differentiation. Epigenetics can also contribute to congenital disorders such as
Angelman syndrome and Prader-Willi syndrome. Epigenetics may also be important in evolution since transgenerational inheritance
of epigenetic modifications has been observed (eg, paramutation in maize). Often however, these modifications are lost after several generations.
Featured Epigenetics Content
Graph epigenetics articles over time -
Plot the number of articles that have been published over time in specific areas of epigenetics research or in all of basic research. You can gauge changes in interest in certain topics and use this to guide your research. It also makes a good introductory slide for a presentation as it demonstrates the importance of your topic.
Recent epigenetics jobs are highlighted here. Jobs are updated twice a day.
Occasionally, we also feature jobs that may be of particular interest to our readers below. Job postings are free for academic and nonprofit
groups. If you would like to post a job, click here.
Browse all of our
epigenetics jobs.
Epigenetics links are profiled and rated. You can rate each website and view the websites in a number of categories
including portals, blogs, databases, software and several other categories. Below you will find the top 10 rated epigenetics
links.
Click here to view the links.
Epigenetics Papers
International Post Genetics Society
Epigenetics Journal
DNA Methylation Database
DNA Methylation Society
Epigenetics? - Epigenome NOE
ScienceRoll
DNA Methylation in Cancer
Geneimprint
Science Functional Genomics Resources: Epigenetics
Recent epigenetics literature is highlighted with this tool. We have taken the entire set of epigenetics articles and
arranged them according to their previous or expected citation rate. This allows you to quickly identify the most important articles in the
field.Articles are updated daily and advance publications are shown before they appear in medline and they are updated every hour.
Click here to use the tool.
Jan 10, '09 - Histone methyltransferasesJan 14, '09 - ChromatinJan 14, '09 - DNA methylation
Recent epigenetics news and press releases are highlighted. We scour over 20,000 news sources to bring you the latest
epigenetics news. The information is updated every 4 hours, so you can be sure to be getting the latest news on the topic.
Click here to view the news.
Epigenetics laboratories are featured here. We have actually profiled nearly 99% of all epigenetics laboratories.
We have also ranked all labs based upon the citation rating of the papers of the principal investigator. Laboratories may alter information on each
lab page including picture, publications, affiliation, and biography. Below you will find the top 20 epigenetics laboratories.
Click here to view the labs.
Dr. JG Herman
Dr. SB Baylin
Dr. R Jaenisch
Dr. M Esteller
Dr. PA Jones
Dr. JP Issa
Dr. W Reik
Dr. AP Feinberg
Dr. CD Allis
Dr. A Bird
Dr. T Jenuwein
Dr. TH Bestor
Dr. MA Surani
Dr. H Cedar
Dr. SE Jacobsen
Dr. S Henikoff
Dr. EU Selker
Dr. M Szyf
Dr. GP Pfeifer
Dr. AP Bird
Featured Epigenetics Structure
Pli E20c Is Antiparallel.
Structure Database
The Epigenetics Database
Browse our epigenetics database which includes all
known epigenetics genes/proteins discovered to-date. The database is arranged
in a hierarchal format based upon gene ontology.It is still in its beta phase, but future
developments include user-submitted meta-data which will be freely available for any use
in database and flatfile format.Browse the epigenetics database
Related Portals
center
Conferences
Our Other Websites
Article Index:
2009
| 2008
| 2007
| 2006
| 2005
| 2004
| 2003
| 2002
| 2001
| 2000
| 1999
| 1998
| 1997
| 1996
| 1995
| 1994
| 1993
| 1992
| 1991
| 1990
Lab Index:
A-B
| C-D
| E-F
| G-H
| I-J
| K-L
| M-N
| O-P
| Q-R
| S-T
| U-V
| W-X
| Y-Z
Jobs Index
| Book Index
| Clinical Trial Index
Copyright copy; 2004-2007 ICMG Ltd.
Medical literature citations were obtained from the National Center for Biotechnology Information. Protein database information
was obtained from the European Bioinformatics Institute.
Life Science Marketing | Protein Crystal Structures laser-etched into crystal | Life Science Market
Research Reports | Journal RSS Feeds | Life Science Trends | Science Social Network | Clinical Trials | Your own research site
| Molecular Structure Rankings | Food, life, and
happiness
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